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rs2708092
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rs1180012
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rs1718125
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|---|
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AA
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AG + GG
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CC
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CT + TT
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GG
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GA + AA
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|---|
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Age (years)
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26.1 ± 7.0
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25.8 ± 7.8
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27.3 ± 7.7
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25.1 ± 7.5
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26.6 ± 7.7
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25.2 ± 7.5
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Male/Female
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32/67
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92/163
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51/77
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74/153
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65/115
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60/115
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|
PPLpre (s)
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15 [10,21]
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14 [9,23]
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14 [9,23]
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14 [9, 23]
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14 [9, 22]
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15 [9, 23]
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|
PPLpost (s)
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29 [18, 52]
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27 [16, 54]
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28 [16, 49]
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28 [16, 54]
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27 [16, 49]
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30 [16, 56]
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|
Analgesic effect (PPLpost-PPLpre) (s)
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15 [5, 35]
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11 [4, 35]
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10 [4, 30]
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13 [4, 36]
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10 [4, 30]
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14 [5, 37]
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24-h postoperative fentanyl use (μg/kg)
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2.2 [1.2, 4.7]
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2.3 [1.0, 4.1]
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2.3 [0.9, 4.1]
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2.3 [1.1, 4.3]
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2.1 [0.9, 3.9]
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2.4 [1.3, 4.4]
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Perioperative fentanyl use (μg/kg)
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7.6 [5.8, 9.2]
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6.7 [5.1, 9.1]
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6.8 [5.0, 9.1]
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7.1 [5.3, 9.1]
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6.8 [5.0, 8.6]
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7.1 [5.5, 9.5]
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Total perioperative analgesic use (μg/kg)
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8.5 [6.7, 10.2]
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7.6 [6.0, 10.1]
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7.7 [5.8, 10.2]
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8.0 [6.2, 10.0]
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7.8 [5.8, 9.6]
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8.0 [6.3, 10.5]
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|
VAS pain score at 3 h (mm)
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27 [15, 47]
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27 [15, 50]
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27 [15, 50]
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30 [15, 50]
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27 [15, 50]
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30 [16, 50]
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|
VAS pain score at 24 h (mm)
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25 [10, 38]
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25 [10, 45]
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22 [8, 40]
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26 [11, 43]
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23 [8, 40]
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28 [14, 46]*
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| |
rs208293
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rs1718136
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rs7132846
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GG
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GA + AA
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AA
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AG + GG
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CC
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CT + TT
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|
Age (years)
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27.5 ± 7.9
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25.2 ± 7.4
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26.2 ± 7.9
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25.4 ± 6.9
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25.7 ± 7.3
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26.8 ± 8.8
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Male/Female
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41/70
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84/160
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95/152
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30/78
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104/170
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21/60
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|
PPLpre (s)
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13 [9, 22]
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15 [9, 24]
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14 [9, 24]
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15 [9, 21]
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14 [9, 23]
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14 [9, 23]
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|
PPLpost (s)
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27 [16, 51]
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28 [16, 54]
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29 [16, 56]
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25 [15, 48]
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28 [16, 53]
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28 [16, 53]
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|
Analgesic effect (PPLpost-PPLpre) (s)
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10 [3, 34]
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13 [5, 35]
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13 [5, 36]
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11 [4, 30]
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12 [4, 35]
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12 [4, 35]
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|
24-h postoperative fentanyl use (μg/kg)
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2.3 [1.1, 4.0]
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2.3 [1.0, 4.3]
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2.3 [1.1, 4.3]
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2.0 [1.0, 4.1]
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2.3 [1.1, 4.2]
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2.3 [1.0, 4.2]
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|
Perioperative fentanyl use (μg/kg)
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6.8 [5.1, 9.0]
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7.1 [5.3, 9.2]
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7.0 [5.2, 9.2]
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6.7 [5.2, 8.9]
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6.9 [5.2, 9.1]
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6.9 [5.2, 9.1]
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Total perioperative analgesic use (μg/kg)
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7.7 [5.9, 10.1]
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8.0 [6.2, 10.1]
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8.0 [6.1, 10.1]
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7.7 [6.1, 9.9]
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8.0 [6.1, 10.1]
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8.0 [6.1, 10.1]
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VAS pain score at 3 h (mm)
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27 [16, 50]
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27 [15, 49]
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27 [15, 50]
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26 [15, 49]
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28 [15, 50]
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27 [15, 50]
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VAS pain score at 24 h (mm)
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22 [10, 39]
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26 [11, 45]
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25 [10, 42]
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25 [8, 42]
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25 [10, 42]
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25 [10, 42]
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- The data are expressed as numbers, mean ± SD (range), or median [interquartile range]. *p <0.05, compared with subjects not carrying minor allele.
